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apalutamide will lessen the level or effect of ethinylestradiol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP3A4 inducer, with medicine that are CYP3A4 substrates can lead to decreased publicity to those drugs.Using tobacco significantly raises the pos